ERVFRD-1

GENE INFORMATION

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Gene name

ERVFRD-1 (HGNC Symbol)

Synonyms

envFRD, ERVFRDE1, HERV-FRD, HERV-W/FRD, syncytin-2

Description

Endogenous retrovirus group FRD, member 1 (HGNC Symbol)

Entrez gene summary

Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of a human endogenous retrovirus provirus on chromosome 6 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Jun 2012]

Chromosome

6

Cytoband

p24.2

Chromosome location (bp)

11102489 - 11111732

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000244476 (version 78.38)

Entrez gene

405754

UniProt

P60508 (UniProt - Evidence at protein level)

neXtProt

NX_P60508

Antibodypedia

ERVFRD-1 antibodies
 

PROTEIN VIEW

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ERVFRD-1-001
 
ERVFRD-1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ERVFRD-1-001 ENSP00000420174
ENST00000472091
P60508
Show all »
Show » Show » 538 59.5 Yes 2
ERVFRD-1-201 ENSP00000444461
ENST00000542862
P60508
Show all »
Show » Show » 538 59.5 Yes 2