HBB

GENE INFORMATION

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Gene name

HBB (HGNC Symbol)

Synonyms

beta-globin, CD113t-C, HBD

Description

Hemoglobin, beta (HGNC Symbol)

Entrez gene summary

The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

p15.4

Chromosome location (bp)

5225464 - 5229395

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000244734 (version 78.38)

Entrez gene

3043

UniProt

P68871 (UniProt - Evidence at protein level)

neXtProt

NX_P68871

Antibodypedia

HBB antibodies
 

PROTEIN VIEW

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HBB-001
 
HBB-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HBB-001 ENSP00000333994
ENST00000335295
P68871
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Show » Show » 147 16 No 0
HBB-004 ENSP00000369671
ENST00000380315
F8W6P5
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Show » Show » 90 9.7 No 0