ALG11

GENE INFORMATION

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Gene name

ALG11 (HGNC Symbol)

Synonyms

KIAA0266

Description

ALG11, alpha-1,2-mannosyltransferase (HGNC Symbol)

Entrez gene summary

This gene encodes a GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase which is localized to the cytosolic side of the endoplasmic reticulum (ER) and catalyzes the transfer of the fourth and fifth mannose residue from GDP-mannose (GDP-Man) to Man3GlcNAc2-PP-dolichol and Man4GlcNAc2-PP-dolichol resulting in the production of Man5GlcNAc2-PP-dolichol. Mutations in this gene are associated with congenital disorder of glycosylation type Ip (CDGIP). This gene overlaps but is distinct from the UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) gene. A pseudogene of the GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase has been identified on chromosome 19. [provided by RefSeq, Aug 2010]

Chromosome

13

Cytoband

q14.3

Chromosome location (bp)

52012398 - 52029664

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000253710 (version 78.38)

Entrez gene

440138

UniProt

Q2TAA5 (UniProt - Evidence at protein level)

neXtProt

NX_Q2TAA5

Antibodypedia

ALG11 antibodies
 

PROTEIN VIEW

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ALG11-001
 
ALG11-002
 
ALG11-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ALG11-001 ENSP00000430236
ENST00000521508
Q2TAA5
Show all »
Show » Show » 492 55.7 No 2
ALG11-002 ENSP00000429497
ENST00000523764
Q5TAP0
Show all »
Show » 36 4 No 0
ALG11-004 ENSP00000481922
ENST00000616513
Show » 30 3.4 No 0