PAK6

GENE INFORMATION

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Gene name

PAK6 (HGNC Symbol)

Synonyms

PAK5

Description

P21 protein (Cdc42/Rac)-activated kinase 6 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

Chromosome

15

Cytoband

q15.1

Chromosome location (bp)

40217428 - 40277486

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000259288 (version 78.38)

Entrez gene

56924

UniProt

neXtProt

Antibodypedia

PAK6 antibodies
 

PROTEIN VIEW

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PAK6-201
 
PAK6-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PAK6-201 ENSP00000406873
ENST00000441369
A0A024R9Q4
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Show » Show » 681 74.9 No 0
PAK6-202 ENSP00000401153
ENST00000453867
A0A024R9Q4
Show all »
Show » Show » 681 74.9 No 0