MMP12

GENE INFORMATION

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Gene name

MMP12 (HGNC Symbol)

Synonyms

HME

Description

Matrix metallopeptidase 12 (macrophage elastase) (HGNC Symbol)

Entrez gene summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

q22.2

Chromosome location (bp)

102862736 - 102875034

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000262406 (version 78.38)

Entrez gene

4321

UniProt

P39900 (UniProt - Evidence at protein level)

neXtProt

NX_P39900

Antibodypedia

MMP12 antibodies
 

PROTEIN VIEW

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MMP12-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MMP12-001 ENSP00000458585
ENST00000571244
P39900
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