HNF1B

GENE INFORMATION

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Gene name

HNF1B (HGNC Symbol)

Synonyms

HNF1beta, LFB3, MODY5, TCF2, VHNF1

Description

HNF1 homeobox B (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

Chromosome

17

Cytoband

q12

Chromosome location (bp)

37686432 - 37745247

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000275410 (version 78.38)

Entrez gene

6928

UniProt

P35680 (UniProt - Evidence at protein level)

neXtProt

NX_P35680

Antibodypedia

HNF1B antibodies
 

PROTEIN VIEW

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HNF1B-001
 
HNF1B-003
 
HNF1B-004
 
HNF1B-005
 
HNF1B-201
 
HNF1B-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HNF1B-001 ENSP00000480291
ENST00000617811
P35680
Show all »
Show » Show » 557 61.3 No 0
HNF1B-003 ENSP00000482711
ENST00000621123
P35680
Show all »
Show » Show » 531 58.4 No 0
HNF1B-004 ENSP00000477524
ENST00000613727
P35680
Show all »
Show » Show » 457 50.3 No 0
HNF1B-005 ENSP00000482529
ENST00000614313
Show » Show » 548 60.2 No 0
HNF1B-201 ENSP00000478682
ENST00000617272
E0YMJ8
Show all »
Show » Show » 425 47.5 No 0
HNF1B-202 ENSP00000481245
ENST00000620125
Show » Show » 293 32.7 No 0