The gene information section lists the gene name (HUGO Gene Nomenclature Committee (HGNC) name if available), any approved gene synonyms, Ensembl gene description, and the Entrez gene summary from the National Center for Biotechnology Information.
The chromosomal and cytoband location of the gene according to Ensembl is reported together with the Ensembl gene identifier and Ensembl database version.
The Entrez gene identifier for the gene is also given. If any of the protein products of
the gene is linked to a UniProt KB/SWISS-PROT entry, links to the UniProt and the
neXtProt databases for these proteins are displayed.
There is also a link to the Antibodypedia portal where validation data for antibodies produced by other suppliers
against this gene can be found.
Gene name
TP73 (HGNC Symbol)
Synonyms
P73
Description
Tumor protein p73 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]
The protein view displays protein features. The tabs at the top of the protein view section can be used to switch between the different splice variants encoded by this gene. The mouse over function displays additional data for the features in the protein view.
At the top of the protein view, the maximum percent sequence identity of the protein to all other proteins from other human genes is shown, using a sliding window of 10 aa residues
(HsID 10) or 50 aa residues (HsID 50) (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS,
SignalP 4.0, and
Phobius
(turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed
(read more), and at the bottom of the protein view is the protein scale.
The protein information section displays the alternative protein-coding transcripts (splice variants) encoded by this gene, according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant.
The data in the UniProt column can be expanded to show links to all matching
UniProt identifiers for this protein.
The protein classes to which this protein has been assigned are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors
SPOCTOPUS,
SignalP 4.0, and
Phobius) and the number of predicted transmembrane region(s) (according to
MDM) are also reported.
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000785 [chromatin] GO:0002039 [p53 binding] GO:0003682 [chromatin binding] GO:0003684 [damaged DNA binding] GO:0003690 [double-stranded DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0005829 [cytosol] GO:0006298 [mismatch repair] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006974 [cellular response to DNA damage stimulus] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0008134 [transcription factor binding] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010165 [response to X-ray] GO:0010332 [response to gamma radiation] GO:0019901 [protein kinase binding] GO:0031571 [mitotic G1 DNA damage checkpoint] GO:0034644 [cellular response to UV] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802 [identical protein binding] GO:0043508 [negative regulation of JUN kinase activity] GO:0043524 [negative regulation of neuron apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0051262 [protein tetramerization]
O15350 [Direct mapping] Tumor protein p73 B7Z3B4 [Target identity:31%; Query identity:100%] cDNA FLJ50534, highly similar to Tumor protein p73 {ECO:0000313|EMBL:BAH12150.1}
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000785 [chromatin] GO:0002039 [p53 binding] GO:0003682 [chromatin binding] GO:0003684 [damaged DNA binding] GO:0003690 [double-stranded DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0005829 [cytosol] GO:0006298 [mismatch repair] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006974 [cellular response to DNA damage stimulus] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0008134 [transcription factor binding] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010165 [response to X-ray] GO:0010332 [response to gamma radiation] GO:0019901 [protein kinase binding] GO:0031571 [mitotic G1 DNA damage checkpoint] GO:0034644 [cellular response to UV] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802 [identical protein binding] GO:0043508 [negative regulation of JUN kinase activity] GO:0043524 [negative regulation of neuron apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0051262 [protein tetramerization]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000785 [chromatin] GO:0002039 [p53 binding] GO:0003682 [chromatin binding] GO:0003684 [damaged DNA binding] GO:0003690 [double-stranded DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0005829 [cytosol] GO:0006298 [mismatch repair] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006974 [cellular response to DNA damage stimulus] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0008134 [transcription factor binding] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010165 [response to X-ray] GO:0010332 [response to gamma radiation] GO:0019901 [protein kinase binding] GO:0031571 [mitotic G1 DNA damage checkpoint] GO:0034644 [cellular response to UV] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802 [identical protein binding] GO:0043508 [negative regulation of JUN kinase activity] GO:0043524 [negative regulation of neuron apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0051262 [protein tetramerization]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000785 [chromatin] GO:0002039 [p53 binding] GO:0003682 [chromatin binding] GO:0003684 [damaged DNA binding] GO:0003690 [double-stranded DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0005829 [cytosol] GO:0006298 [mismatch repair] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006974 [cellular response to DNA damage stimulus] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0008134 [transcription factor binding] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010165 [response to X-ray] GO:0010332 [response to gamma radiation] GO:0019901 [protein kinase binding] GO:0031571 [mitotic G1 DNA damage checkpoint] GO:0034644 [cellular response to UV] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802 [identical protein binding] GO:0043508 [negative regulation of JUN kinase activity] GO:0043524 [negative regulation of neuron apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0051262 [protein tetramerization]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000785 [chromatin] GO:0002039 [p53 binding] GO:0003682 [chromatin binding] GO:0003684 [damaged DNA binding] GO:0003690 [double-stranded DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0005829 [cytosol] GO:0006298 [mismatch repair] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006974 [cellular response to DNA damage stimulus] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0008134 [transcription factor binding] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010165 [response to X-ray] GO:0010332 [response to gamma radiation] GO:0019901 [protein kinase binding] GO:0031571 [mitotic G1 DNA damage checkpoint] GO:0034644 [cellular response to UV] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802 [identical protein binding] GO:0043508 [negative regulation of JUN kinase activity] GO:0043524 [negative regulation of neuron apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0051262 [protein tetramerization]
O15350 [Direct mapping] Tumor protein p73 B7Z3B4 [Target identity:32%; Query identity:100%] cDNA FLJ50534, highly similar to Tumor protein p73 {ECO:0000313|EMBL:BAH12150.1}
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000785 [chromatin] GO:0002039 [p53 binding] GO:0003682 [chromatin binding] GO:0003684 [damaged DNA binding] GO:0003690 [double-stranded DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0005829 [cytosol] GO:0006298 [mismatch repair] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006974 [cellular response to DNA damage stimulus] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0008134 [transcription factor binding] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010165 [response to X-ray] GO:0010332 [response to gamma radiation] GO:0019901 [protein kinase binding] GO:0031571 [mitotic G1 DNA damage checkpoint] GO:0034644 [cellular response to UV] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802 [identical protein binding] GO:0043508 [negative regulation of JUN kinase activity] GO:0043524 [negative regulation of neuron apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0051262 [protein tetramerization]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000785 [chromatin] GO:0002039 [p53 binding] GO:0003682 [chromatin binding] GO:0003684 [damaged DNA binding] GO:0003690 [double-stranded DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0005829 [cytosol] GO:0006298 [mismatch repair] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006974 [cellular response to DNA damage stimulus] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0008134 [transcription factor binding] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010165 [response to X-ray] GO:0010332 [response to gamma radiation] GO:0019901 [protein kinase binding] GO:0031571 [mitotic G1 DNA damage checkpoint] GO:0034644 [cellular response to UV] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802 [identical protein binding] GO:0043508 [negative regulation of JUN kinase activity] GO:0043524 [negative regulation of neuron apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0051262 [protein tetramerization]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000785 [chromatin] GO:0002039 [p53 binding] GO:0003682 [chromatin binding] GO:0003684 [damaged DNA binding] GO:0003690 [double-stranded DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0005829 [cytosol] GO:0006298 [mismatch repair] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006974 [cellular response to DNA damage stimulus] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0008134 [transcription factor binding] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010165 [response to X-ray] GO:0010332 [response to gamma radiation] GO:0019901 [protein kinase binding] GO:0031571 [mitotic G1 DNA damage checkpoint] GO:0034644 [cellular response to UV] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802 [identical protein binding] GO:0043508 [negative regulation of JUN kinase activity] GO:0043524 [negative regulation of neuron apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0051262 [protein tetramerization]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000785 [chromatin] GO:0002039 [p53 binding] GO:0003682 [chromatin binding] GO:0003684 [damaged DNA binding] GO:0003690 [double-stranded DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0005829 [cytosol] GO:0006298 [mismatch repair] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006974 [cellular response to DNA damage stimulus] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0008134 [transcription factor binding] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010165 [response to X-ray] GO:0010332 [response to gamma radiation] GO:0019901 [protein kinase binding] GO:0031571 [mitotic G1 DNA damage checkpoint] GO:0034644 [cellular response to UV] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802 [identical protein binding] GO:0043508 [negative regulation of JUN kinase activity] GO:0043524 [negative regulation of neuron apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0051262 [protein tetramerization]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000785 [chromatin] GO:0002039 [p53 binding] GO:0003682 [chromatin binding] GO:0003684 [damaged DNA binding] GO:0003690 [double-stranded DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0005829 [cytosol] GO:0006298 [mismatch repair] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006974 [cellular response to DNA damage stimulus] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0008134 [transcription factor binding] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010165 [response to X-ray] GO:0010332 [response to gamma radiation] GO:0019901 [protein kinase binding] GO:0031571 [mitotic G1 DNA damage checkpoint] GO:0034644 [cellular response to UV] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802 [identical protein binding] GO:0043508 [negative regulation of JUN kinase activity] GO:0043524 [negative regulation of neuron apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0051262 [protein tetramerization]
