NDUFA1

GENE INFORMATION

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Gene name

NDUFA1 (HGNC Symbol)

Synonyms

CI-MWFE, MWFE

Description

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa (HGNC Symbol)

Entrez gene summary

The human NDUFA1 gene codes for an essential component of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. It has been noted that the N-terminal hydrophobic domain has the potential to be folded into an alpha-helix spanning the inner mitochondrial membrane with a C-terminal hydrophilic domain interacting with globular subunits of complex I. The highly conserved two-domain structure suggests that this feature is critical for the protein function and might act as an anchor for the NADH:ubiquinone oxidoreductase complex at the inner mitochondrial membrane. However, the NDUFA1 peptide is one of about 31 components of the ""hydrophobic protein"" (HP) fraction of complex I which is involved in proton translocation. Thus the NDUFA1 peptide may also participate in that function. [provided by RefSeq, Jul 2008]

Chromosome

X

Cytoband

q24

Chromosome location (bp)

119871487 - 119876662

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000125356 (version 78.38)

Entrez gene

4694

UniProt

O15239 (UniProt - Evidence at protein level)

neXtProt

NX_O15239

Antibodypedia

NDUFA1 antibodies
 

PROTEIN VIEW

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NDUFA1-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NDUFA1-001 ENSP00000360492
ENST00000371437
O15239
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