PARP1

GENE INFORMATION

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Gene name

PARP1 (HGNC Symbol)

Synonyms

ADPRT, PARP, PPOL

Description

Poly (ADP-ribose) polymerase 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

q42.12

Chromosome location (bp)

226360691 - 226408075

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000143799 (version 78.38)

Entrez gene

142

UniProt

P09874 (UniProt - Evidence at protein level)

neXtProt

NX_P09874

Antibodypedia

PARP1 antibodies
 

PROTEIN VIEW

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PARP1-001
 
PARP1-003
 
PARP1-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PARP1-001 ENSP00000355759
ENST00000366794
P09874
Show all »
Show » Show » 1014 113.1 No 0
PARP1-003 ENSP00000355755
ENST00000366790
Q5VX85
Show all »
Show » Show » 155 17.3 No 0
PARP1-005 ENSP00000355757
ENST00000366792
Q5VX84
Show all »
Show » Show » 108 12.2 No 0