CDK5R1

GENE INFORMATION

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Gene name

CDK5R1 (HGNC Symbol)

Synonyms

Nck5a, p35nck5a

Description

Cyclin-dependent kinase 5, regulatory subunit 1 (p35) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q11.2

Chromosome location (bp)

32486619 - 32491256

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000176749 (version 78.38)

Entrez gene

8851

UniProt

Q15078 (UniProt - Evidence at protein level)

neXtProt

NX_Q15078

Antibodypedia

CDK5R1 antibodies
 

PROTEIN VIEW

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CDK5R1-001
 
CDK5R1-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDK5R1-001 ENSP00000318486
ENST00000313401
Q15078
Show all »
Show » Show » 307 34.1 No 0
CDK5R1-003 ENSP00000464129
ENST00000584792
Show » Show » 115 12 No 0