EIF4EBP1

GENE INFORMATION

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Gene name

EIF4EBP1 (HGNC Symbol)

Synonyms

4E-BP1, PHAS-I

Description

Eukaryotic translation initiation factor 4E binding protein 1 (HGNC Symbol)

Entrez gene summary

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]

Chromosome

8

Cytoband

p11.23

Chromosome location (bp)

38030341 - 38060365

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000187840 (version 78.38)

Entrez gene

1978

UniProt

Q13541 (UniProt - Evidence at protein level)

neXtProt

NX_Q13541

Antibodypedia

EIF4EBP1 antibodies
 

PROTEIN VIEW

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EIF4EBP1-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EIF4EBP1-001 ENSP00000340691
ENST00000338825
Q13541
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